How can the Niacin-flush be minimized or even prevented in formulating a cosmetic product with Nicomenthyl 20?

The potential mild Niacin-flush can be avoided or further minimized in two ways:

  • Decreasing the concentration of Nicomenthyl 20 in the formulation, down to 0.5% or even less.
  • Formulating a more “anhydrous” composition, with less glycols and more oily ingredients (such as waxes), to slow down the skin penetration of menthyl nicotinate. This will extend the time-release absorption and prevent the flush effect or make it almost unperceivable, still maintining an optimal detox efficacy.