NIACINA

MECHANISM OF FLUSHING DUE TO NIACIN AND ABOLITION OF THESE EFFECTS

There are many factors that increase the risk of cardiovascular disease, and a prominent factor among these is dyslipidemia. The following literature review focuses on the use of niacin therapy in order to treat dyslipidemia and how to control the associated ‘‘niacin flush.’’ The associated studies gathered are reviews and randomized control trials. They were obtained by using electronic searches. Certain keywords took precedence, and articles focusing on niacin therapy were chosen.

NIACIN FOR DETOXIFICATION: A LITTLE-KNOWN THERAPEUTIC USE

Abstract: Niacin (nicotinic acid) has a number of well-established clinical uses and the potential for additional clinical applications. To date, its therapeutic application for enhancing detoxification has not been systematically reviewed. The use of niacin for the purpose of enhancing detoxification was popularized by L. Ron Hubbard (i.e., the founder of the Church of Scientology) in 1977. He developed a comprehensive detoxification method using niacin and other treatments to remove lipid-stored xenobiotics.

THE MECHANISM AND MITIGATION OF NIACIN-INDUCED FLUSHING

Niacin, either alone or in combination with a statin, safely and effectively addresses most lipid abnormalities in patients with mixed dyslipidaemia. Therapeutically used for more than 50 years, niacin is the most effective clinically available agent for increasing high-density lipoprotein cholesterol (HDL-C) levels. In most patients, niacin increases HDL-C by 20–40% (1–5). Niacin also has beneficial effects on all known pro-atherogenic lipid parameters, including lowering low-density lipoprotein cholesterol (LDL-C), non-HDL-C and triglycerides.