Relationships with Niacin and Menthol

Is the so called Niacin-flush (temporary skin redness) an allergic reaction?

Absolutely not. Some people misinterpret the Niacin flush (vasodilation) as an allergic reaction. There is a similarity but they are not the same. The flush caused by an allergy may be due to a local release of histamine into the epithelial tissues, triggered by the presence of allergens. The Niacin-flush instead is the result of a complex cascade of chemical reactions which, apart from activating some specific skin thermoreceptors, produce substances known as prostaglandins (PGD2 e PGE2), responsible for a temporary skin vasodilation.

Is Nicomenthyl liable to cause allergies?

Thorough in vitro testing has confirmed that Nicomenthyl is not sensitizing.
As a precaution however, considering that Nicomenthyl slowly releases Menthol into the skin, we advise the subject allergic to that substance to test first the cosmetic product containing Nicomenthyl by applying a small quantity of it inside the forearm.

What is the difference between nicotinic acid and niacin?

None. Nicotinic acid and Niacin are synonyms, both terms indicating the same molecule. Nicotinic acid = Niacin = Vitamin B3 = Vitamin PP (Pellagra Preventing). Deficiency of Vitamin B3 is the cause of Pellagra, a dreadful desease, characterized by the famous 4 “D”s:  dermatitis, diarrhea, dementia and death.

Why is nicotinic acid called this way?

In 1873 the Austrian chemist Hugo Weidel managed to synthetize it by oxidizing nicotine with nitric acid. This has been the only reason this substance was then called “Nicotinic” acid, even though it was not biochemically or toxicologically related to the well-known tobacco alkaloid.

Has Menthyl nicotinate anything to do with nicotine?

NO, there is no functional relationship between Menthyl nicotinate and Nicotine. Niacin or Vitamin B3 was originally given the name of nicotinic acid by Austrian chemist Hugo Weidel in 1873. Having obtained it by oxidizing Nicotine he called it “Nicotinic acid”.