Frequently Asked Questions about Nicomenthyl

Relationships with Niacin and Menthol

NO, there is no functional relationship between Menthyl nicotinate and Nicotine. Niacin or Vitamin B3 was originally given the name of nicotinic acid by Austrian chemist Hugo Weidel in 1873. Having obtained it by oxidizing Nicotine he called it “Nicotinic acid”.
The discovery that Niacin was a vitamin was made in 1937 by the American chemist Conrad Elvehjem. A few years later, in 1942, the American Medical Association gave this substance a more popular name less misleading than Nicotinic acid, to prevent illogical, unfounded associations between the harmful effects of Nicotine and the therapeutic ones of vitamins. Its new name became NI AC IN, from the first two letters of NIcotinic ACid, and the last two letters of vitamIN.

In 1873 the Austrian chemist Hugo Weidel managed to synthetize it by oxidizing nicotine with nitric acid. This has been the only reason this substance was then called “Nicotinic” acid, even though it was not biochemically or toxicologically related to the well-known tobacco alkaloid.

None. Nicotinic acid and Niacin are synonyms, both terms indicating the same molecule. Nicotinic acid = Niacin = Vitamin B3 = Vitamin PP (Pellagra Preventing). Deficiency of Vitamin B3 is the cause of Pellagra, a dreadful desease, characterized by the famous 4 “D”s:  dermatitis, diarrhea, dementia and death.

Niacin plays an essential metabolic role throughout the animal kingdom. It is the precursor of important cellular coenzymes such as NAD e NADP, essential for energetic metabolism of skin cells; it is needed for red blood cell formation, increased transport of oxygen and nutrients, removal of toxins & cellular waste products through skin microcirculation; it reduces triglycerides and cholesterol levels, prevents cardiovascular diseases, helps maintain skin barrier integrity, healthy nervous system functioning and brain activity (its deficiency may cause serious mental illnesses); it plays a key role in synthesis of sex hormones estrogen, progesterone, and testosterone, etc.

Scientific studies have revealed that, in 24 hours, the quantity of Niacin released in the skin is about 18% of the total niacin contained in the original dose of Nicomenthyl.

Menthol exerts an essential balsamic and soothing activity. The simultaneous and equi-molar release of menthol into the skin prevents the niacin-flush effect that is usually observed with other nicotinate-based formulations, without however inhibiting its biochemical and vitaminic functionality.

Thorough in vitro testing has confirmed that Nicomenthyl is not sensitizing.
As a precaution however, considering that Nicomenthyl slowly releases Menthol into the skin, we advise the subject allergic to that substance to test first the cosmetic product containing Nicomenthyl by applying a small quantity of it inside the forearm.

Absolutely not. Some people misinterpret the Niacin flush (vasodilation) as an allergic reaction. There is a similarity but they are not the same. The flush caused by an allergy may be due to a local release of histamine into the epithelial tissues, triggered by the presence of allergens. The Niacin-flush instead is the result of a complex cascade of chemical reactions which, apart from activating some specific skin thermoreceptors, produce substances known as prostaglandins (PGD2 e PGE2), responsible for a temporary skin vasodilation.
The production of prostaglandins is the very factor that brings about a higher oxygenation and nourishment of tissues as well as a more effective and simultaneous elimination of toxins and cellular metabolic waste in the flushed skin area. There isn’t any allergen-related reaction in this mechanism. On the contrary, it is an oxygenating, nourishing and detox mechanism, initiated by Niacin.