Frequently Asked Questions about Nicomenthyl

Nicomenthyl compared to other niacin derivates

They are completely different substances, with completely different molecular structures:

metil nicotinato

Methyl nicotinate

mentil nicotinato

Menthyl nicotinate

Methyl nicotinate is a very strong vasodilating agent and can be in some cases highly irritating to the skin even at very low concentrations (0.1% or less). Menthyl nicotinate (Nicomenthyl) effectively enhances skin microcirculation without causing bothersome hyperemia or irritations, on the contrary it generates a pleasant hot-cold sensation in the area of application.

Niacinamide (also called Nicotinamide), although it is considered another form of Vitamin B3, has a different chemical structure than nicotinic acid. It is a derivative of nicotinic acid, chemically named amide of nicotinic acid:


Niacin or nicotinic acid


Nicotinamide or Niacinamide

No, Niacinamide has no vasodilating activity. It is not a microcirculation enhancer.

No. Since Niacinamide is hydrosoluble, its transcutaneous absorption in 24 hours is only 2.2% of the initially applied dose. Such quantities are very low compared to the amount of Vitamin B3 released by Nicomenthyl (liposoluble) in the same period of time. Such amount reaching a rate of approx. 18% of the Vitamin B3 contained in the applied dose of Nicomenthyl 20. Therefore, Nicomenthyl delivers approx. 8 times more Vitamin B3 than Niacinamide.

No, Nicomenthyl 20 is not a whitening agent. On the contrary, it tends to increase cutaneous pigmentation (melanin), while effectively preventing and protecting the skin against UVA and UVB rays damages.

Yes, certainly. There is no incompatibility between these two substances.

Because it ensures the highest and fastest delivery of Vitamin B3 with no skin irritation or sensitization, as thoroughly documented by several safety and efficacy tests.